Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. The human homologue of this …

Nov 25, 2020 · MDM2 amplification and overexpression in tumors is associated with radiation, chemotherapy, tyrosine kinase inhibitor and immune checkpoint inhibitor resistance (Cancer Cell Int …

We herein summarize the research efforts to discover and develop MDM2 inhibitors, focusing on those that induce MDM2 degradation and exert anticancer activity, regardless of the p53 status of the cancer.

Nov 14, 2025 · Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex.

May 13, 2024 · Abstract Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed to function as a negative …

Nov 1, 2024 · Abstract Murine double minute 2 (MDM2) plays an essential role in the cell cycle, apoptosis, DNA repair, and oncogene activation through p53-dependent and p53-independent …

4 days ago · Lysosomal activation via the MDM2-P53-V-ATPase axis unveils a potent host-directed strategy for eradicating intracellular pathogens and potentiating conventional antimicrobial therapy.

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53, playing a key role in controlling its transcriptional activity, protein stability, and nuclear localization. MDM2 …

Jun 14, 2023 · The MDM2 reprograms many biological processes that support malignant transformations e.g., cell growth, angiogenesis, metabolism, apoptosis evasion, and metastasis [6]. …

Momand et al. (1992) found that the mdm2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. Forming a tight complex with the p53 …