Aug 24, 2021 · In this study, a bioinformatics analysis is conducted to screen differentially expressed miRNAs and mRNAs in laryngeal squamous cell carcinoma (LSCC). Based on this information, we explored the possible roles of miRNAs in the pathogenesis of LSCC.

MicroRNAs (miRNAs) regulating the DEGs were predicted using WebGestalt. A total of 461 DEGs were identified in LSCC, 297 of which were upregulated and 164 of which were downregulated.

This study aims to construct a systematic mRNA-miRNA-lncRNA network to identify novel lncRNAs and miRNAs biomarkers for laryngeal squamous cell carcinoma (LSCC). The mRNA, miRNA and lncRNA expression profiles of LSCC were obtained from Gene ...

OIP5-AS1 was confirmed to serve as a competing endogenous RNA (ceRNA) of miR-204-5p in LSCC cells. ZEB1 is a target gene of miR-204-5p in LSCC. The restoration of miR-204-5p expression counteracts the carcinogenic effect mediated by OIP5-AS1 (Wang et al., 2020).

Lung squamous cell carcinoma (LSCC) is a common cancer worldwide, and this study aimed to investigate the key regulatory networks and prognostic indicators of LSCC. MicroRNA (miRNA)/messenger RNA (mRNA) sequencing and DNA methylation data were obtained from the Cancer Genome Atlas.

6 days ago · Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer diagnosis and prognosis. This systematic review aims to identify circulating miRNAs associated with LSCC, emphasizing those validated by at least two independent studies to improve reliability and clinical applicability.

Jun 15, 2020 · To identify the lncRNAs related to LSCC pathogenesis, we downloaded and analyzed online microarray expression profiles, GSE84957, GSE59102, and GSE51985, and found that a total of 362 genes were differentially-expressed in LSCC and normal tissue samples. Gene Ontology (GO) functional enrichment analysis was performed on these differentially ...

Aug 4, 2023 · The performance of six-miRNAs signature described in the current study demonstrated remarkable potential for progression assessment of LSCC. Moreover, the six-miRNAs signature may serve as predictive tool for prognosis and therapeutic targets of …

Sep 24, 2021 · Downregulation of miR-1207-5p was found to be strongly linked to the malignant progression of LSCC. Functional studies revealed that miR-1207-5p upregulation suppressed LSCC cell proliferation, invasion, migration, and xenograft tumor growth.

To analyze the genes directly influenced by miR-144-3p in LSCC, a double-channel GSE56243 (GSM1357599) microarray was used, and it identified the differentially expressed genes (DEGs) after overexpressing miR-144-3p in LSCC Fadu cell lines.