Because CD3 is required for T-cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes …

Nov 14, 2025 · The CD3 complex acts as the signal transducer, translating external recognition by the TCR into internal cellular action. The complex is composed of multiple protein chains, typically …

Aug 4, 2025 · CD3 (Cluster of Differentiation 3) is a protein complex found on the surface of T cells. It acts as a universal marker for T cells, used to identify and count T cells.

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of signaling events.

In this review, we will focus on those strategies that directly target the CD3/TCR complex in situ—namely, CD3 specific antibodies, their variants, and CD3 aptamers (Table 1).

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

What is CD3? CD3 is a protein that is normally made by two types of specialized immune cells, T cells and NK cells. Most lymphomas that start from T and NK cells, including peripheral T cell lymphoma, …

Jan 2, 2026 · CD3 (Cluster of Differentiation 3) is a multi-subunit protein complex expressed exclusively on the surface of T cells. It is an integral component of the T cell receptor (TCR) complex and is …

Jun 7, 2024 · CD3 is a protein complex found on the surface of T cells, a type of white blood cell that is central to the immune response. The CD3 complex is composed of several subunits: CD3γ, CD3δ, …

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are …