Astrocytes, the Gatekeepers of Norepinephrine Signaling in the Brain ...
Jun 6, 2025 · Norepinephrine modulates neuronal synapses by way of astrocyte adrenergic receptors. The astrocytes release ATP, which converts to adenosine, a neuromodulator that binds nearby …
Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · Two different reactive astrocyte clusters showed enrichment for genes that were positively correlated with the degree of p-tau pathology, suggesting that these astrocyte phenotypes may be …
Alleviating symptoms of neurodegenerative disorders by astrocyte ...
Oct 4, 2023 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach for treating …
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Mar 7, 2025 · EphA4 inhibition counteracted both astrocyte reactivity and synaptic engulfment. EphA4 expression rose in both neurons and astrocytes with worsening amyloidosis, but was neuronal or …
GPCR signaling gates astrocyte responsiveness to neurotransmitters …
Jun 6, 2025 · Collectively, these papers highlight the critical and diverse roles of astrocytes in mediating the effects of norepinephrine, and related neuromodulators such as tyramine and octopamine, on …
Astrocyte reactivity influences amyloid-β effects on tau ... - ALZFORUM
Jun 2, 2023 · Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 Jul;29 (7):1775-1781. Epub 2023 May 29 PubMed.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Strikingly, a sub-type of astrocyte was the only cell group that tracked with cognitive resilience. They expressed a cadre of genes, including HMGN2, NQO1, GPX3, and ODC1, which …
“iAssembloids” Probe Glial Roles in Neuron Survival | ALZFORUM
Jan 24, 2025 · To learn what astrocyte ApoE4 might be doing, the scientists compared iAssembloids in which astrocytes expressed ApoE4 with those containing astrocytes that produced ApoE3. More …
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 ...
Jun 5, 2024 · We wish to highlight that these other, more numerous, astrocyte populations can contribute to neuroinflammation and neurodegeneration in different ways. Indeed, the interesting …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Neurons promptly export, and glia import, these toxic molecules, isolating them within lipid droplets. AD risk factors may compromise this cleanup pathway. Previous work from Bellen’s lab …