B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene. [5][6][7] The BCL11A gene encodes for a regulatory C2H2 type zinc-finger protein, that can bind to the DNA. Five alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported. [7] .

Dec 24, 2024 · BCL11A (BCL11 Transcription Factor A) is a Protein Coding gene. Diseases associated with BCL11A include Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin and Intellectual Disability-Hypoplastic Corpus Callosum-Preauricular Tag Syndrome.

Dec 5, 2020 · BCL11A is a transcription factor that represses γ-globin expression and fetal hemoglobin in erythroid cells. We performed electroporation of CD34+ hematopoietic stem and progenitor cells...

Nov 29, 2019 · BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching. The expression of this gene is regulated by microRNAs, transcription factors and genetic variations.

Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching.

Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N …

Dec 5, 2020 · BCL11A is a repressor of γ-globin expression and HbF production in adult erythrocytes. Its down-regulation is a promising therapeutic strategy for induction of HbF. We enrolled...

Nov 2, 2023 · However, despite an elevated level, cells expressing monomeric BCL11A are defective in HbF silencing, indicating that the tetramer structure is critical for γ-globin repression. Our findings provide novel insights into BCL11A action …

Here, we provide a brief overview of the fetal-to-adult hemoglobin switch that occurs in humans shortly after birth and review our current understanding of one of the most potent known regulators of this switching process, the multiple zinc …

In this study, one ZFN pair, two TALEN pairs, and four CRISPR gRNAs, all designed to target exon 2 of the transcriptional repressor of HbF—the BCL11A gene, were evaluated for efficacy, specificity, and toxicity in human cell lines and primary CD34 + cells.