The Chargers' defense got lit up by the Colts on Sunday, but Los Angeles head coach Jim Harbaugh was not one to criticize it after the game.

The Los Angeles Chargers host the Indianapolis Colts in Week 7, returning to a rather standard kickoff time and TV channel comfort zone in the process. Those Chargers have a chance to seize first place in the AFC outright with a win, which would let them move to 5-2 and become winners of two in a row.

Daniel Jones threw for 288 yards and two touchdowns as the Indianapolis Colts beat the Los Angeles Chargers 38-24.

The Indianapolis Colts have proven to be one of the biggest NFL surprises in 2025 after starting off 5-1 and dispatching of another challenging opponent in Week 7 with relative ease. RELATED: Sean Payton offers massive praise to New York Giants rookie QB after wild comeback win The AFC South franchise has become one

The Colts were already one of the top positive surprises of the season before an impressive 38-24 win at the Los Angeles Chargers on Sunday afternoon.

The Los Angeles Chargers have a shot at stealing the AFC’s top overall seed if they can win against the visiting Indianapolis Colts in Week 7.

In hindsight, perhaps it was not the best look for a team riddled with key injuries to be dressed like banana peels.

The Los Angeles Chargers' uniforms against the Indianapolis Colts pay homage to their early days and evoke jokes from the CBS announcers.

The Indianapolis Colts visit the Los Angeles Chargers in NFL Week 7 action: Expert predictions, picks, scouting report, who has the edge.

You've seen the model's best bets for Los Angeles Chargers vs. Indianapolis Colts. Now, get against the spread, total and money-line picks for every Week 7 NFL game here, all from the model that's simulated every game 10,000 times.