In the microscopic world inside a stem cell, some of the most important decisions about life’s earliest stages come down to only a handful of molecules. A new study from UNC Charlotte shows that just ...
A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large‑scale gene-silencing structures inside cells, and what happens when that process breaks down. The ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
Dysregulation of the polycomb repressive complex 2 (PRC2) is associated with epigenetic silencing of tumor suppressor genes, leading to alterations in cell proliferation, differentiation and survival ...
Evidence points that DNA double-strand breaks (DSBs) mobilize to different nuclear compartments, notably to the nuclear periphery. This phenomenon, primarily characterized in yeast, is only beginning ...
Researchers from the School of Veterinary Medicine and Perelman School of Medicine have found that YY1 knockout pro-B cells can generate T lineage cells helping B cells produce antibodies. Development ...
Development of B cells, white blood cells that make antibodies, follows a progression of stages: common lymphoid progenitors, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and then more ...
One of the most fascinating discoveries in biology is that cells have mechanisms for dynamically regulating genetic expression. This ability to promote or restrict the transcription of specific genes ...
The roots of cancer run deep. Indeed, they’re usually assumed to run all the way to the blighted bits of DNA we call oncogenic mutations. But what if they don’t have to run quite that deep? What if ...
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