Clinically, exacerbation manifestations may include worsening ptosis, ophthalmoparesis, bulbar dysfunction, proximal limb weakness, and in severe cases, respiratory distress, which can lead to ...

3 While the split-hand phenomenon is more commonly observed in spinal-onset ALS, it is also observed in bulbar onset ALS as well as patients ... Weber and colleagues suggested that preferential ...

and perhaps also for other patients with bulbar-innervated muscle dysfunction. Video-recorded flexible laryngoscopy is a feasible method to characterise laryngeal responses throughout an MI-E protocol ...

Symptoms often include oral-bulbar dysfunction or aphasia, suggesting left hemisphere vulnerability due to its role in language and motor control. This laterality effect is an observation rather than ...

Sleep quality measures including arousal indices were not influenced by the extent of bulbar dysfunction (data not shown). In order to investigate the interplay of SDB, functional status and disease ...

The patient eventually recovered, but subsequent work-up demonstrated severe bulbar dysfunction with evidence of aspiration. Two months after discharge, the patient arrived at the hospital in a ...

Therefore, dysfunction of DPP6 can lead to significant health consequences. Abnormal DPP6 expression has been identified in several diseases, such as amyotrophic lateral sclerosis (ALS), autism ...

How to address metabolic dysfunction can be challenging. We know the factors: a poor diet with lots of ultra-processed foods, a lack of exercise, poor sleep habits, smoking, excessive alcohol ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.