Frontiers19d
Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor
Results: By integrating snRNA-seq and bulk RNA-seq data, we identified a subtype of Scissor+ tumor cells associated with poor RFS, predominantly derived from cap mesenchyme-like blastemal and ...
BioWorld25d
MEOX1 signaling behind the pathogenesis of IBD, study finds
Investigating the relationship between IL-1 and inflammation in inflammatory bowel disease (IBD), researchers unveiled mesenchyme homeobox 1 (MEOX1), an IL-1-dependent transcription factor that is ...
Frontiers2y
Embryology of the Abdominal Wall and Associated Malformations—A Review
In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic ...
eLife2y
Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling
Production and emigration of neural crest cells is a transient process followed by the emergence of the definitive roof plate. The mechanisms regulating the end of neural crest ontogeny are poorly ...
eLife3y
Paraxial mesoderm organoids model development of human somites
Budjan et al. describe an organoid protocol to obtain somite-like structures from human iPSCs. Using defined culture media, the authors describe the formation after 5 days in vitro of organoids that ...