Staying on top of your health involves more than just feeling good – it's about knowing what's happening beneath the surface.

Cytoplasmic maturation, leading to platelet production, cannot be equated with increasing degrees of polyploidy, for DNA synthesis occurs only in the precursor cells and megakaryoblasts and not in ...

Blood platelets are anucleate cells essential for normal blood hemostasis. To maintain a normal platelet count of 150 000 to 400 000 per μL of blood, 1011 platelets must be released each day from ...

Conversely, HMGA2 KO mice showed a reduced number of HSCs and platelet precursor cells. Professor Sashida explained the findings: “Our studies reveal that HMGA2 interacts with chromatin in ...

The mechanism of platelet formation is not fully understood. Megakaryocytes (MKs), platelet precursors, reside in the bone marrow but release proplatelets and platelets only once they enter the blood.

However, later studies confirmed that anucleate platelets possess complete elements (Dicer, Ago2, and TRBP2) which can machine precursor miRNA (pre-miRNA) into mature miRNA in their cytoplasm (27), ...

The physiological function of amyloid β precursor protein (APP) in platelets has remained elusive. Upon platelet activation, APP localizes to the platelet surface and is proteolytically processed by ...

However, there is another systemic source of APP and Aβ: platelets, which are small nuclear cells formed from the pro-platelet processes of the megakaryocyte (MK) precursor cell (100, 101).

Many viruses interact with platelets and their precursor cells, megakaryocytes, leading to the enhanced expression of type I interferon genes, platelet-mediated transport, and protease activation.