The lac operon system of E. coli has been utilized widely for both experimental and industrial purposes. The lacZ gene, which encodes β-galactosidase, is used most extensively as a reporter gene ...

The operon is regulated by Lac repressor, the product of the lacI gene, which is transcribed from its own promoter (PI). The repressor inhibits transcription by binding to the lac operator (O).

Nature Reviews Microbiology - cAMP does not have an important role in carbon catabolite repression of the Escherichia coli lac operon. Skip to main content. Thank you for visiting nature.com.

Monod and Jacob's lac operon turned out to be the first of many bacterial operons. ... To further test the idea, Igoshin and Ray examined the operon organization of the E. coli genome.