The first healthy volunteer has been dosed in a Phase 1 study of Cellarity's novel globin-switching therapy CLY-124 for ...

Japan: Researchers have found in a new study that Roxadustat therapy in non-dialyzed chronic kidney disease (CKD) patients may lead to hemoglobin (Hb) overshoot, particularly when switching ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

Nintendo’s Switch 2, the Mario-and-Zelda company’s first new gaming console in eight years, is being released worldwide on Thursday. How is it different? Have tariffs affected prices? What are ...

During the switch from human γ‐ (fetal) to β‐ (adult) globin gene expression, the γ and β genes are expressed competitively by an alternating transcription mechanism. The −50 region of the γ gene ...

Target-range hemoglobin levels were maintained over 1 year in patients on dialysis switching from the long-acting ESA to thrice-weekly vadadustat.

In a phase 3B study, iptacopan demonstrated improved hemoglobin levels in adult patients with PNH who switched from anti-C5 therapies.

The data show BCH-BB694 “reverses the fetal-to-adult hemoglobin switch and induces [red blood cells] with higher HbF%, lower HbS%, and greater resistance to … polymerization in clinical trial subjects ...

BACKGROUND: There is ambiguity whether frail patients with atrial fibrillation managed with vitamin K antagonists (VKAs) should be switched to a non–vitamin K oral anticoagulant (NOAC). METHODS: We ...

Sickle cells are stiff, inflexible red blood cells that can get stuck in blood vessels, leading to health complications. Learn how they differ from healthy red blood cells.