Computational simulator targets intervertebral disk biochemistry to find most common cause of back pain
UPF researchers have led the creation of a computational simulator that is unique in the world to study one of the causes of ...
eLife14d
Normal and dysregulated crosstalk between iron metabolism and erythropoiesis
Recent evidence regarding the crosstalk between erythropoiesis and iron metabolism sheds light on the regulation ... iron complexed within the porphyrin ring of heme, and iron within iron-sulfur ...
Frontiers17d
Editorial: Heme proteins: key players in the regulation of immune responses
Heme is the iron-containing prosthetic group of heme proteins, with varied functions ranging from gas carriers (i.e., hemoglobin) to metabolic enzymes (i.e., cytochromes, indoleamine dioxygenases).
The EMBO Journal18d
Arginine: at the crossroads of nitrogen metabolism
This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...
Cancer Research18d
Gut Microbiota–Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression
1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. 2Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, China. 7Suzhou Biomedical ...
Imperial College London24d
Novel fluorescent chemical that detects Heme Oxygenase 1
showing that porphyrin catabolism was regioselective at the α-position. Finally, through the analysis of a control inactive analogues, we showed that close structural analogues of heme are required to ...
C&EN1mon
Defluorination of Fluorophenols by a Heme Dehaloperoxidase: Insights into the Defluorination Mechanism
Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom Department of Chemical Engineering, The University of Manchester, Oxford ...
Frontiers2y
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
The liberation of heme has been linked to the activation of inflammatory systems, including the complement system, through alternative pathway activation. Here, we investigated the impact of heme on ...
eLife7y
Prediction of enzymatic pathways by integrative pathway mapping
We demonstrate this integrative pathway mapping method by predicting the L-gulonate catabolic pathway in Haemophilus influenzae Rd KW20. The prediction was subsequently validated experimentally by ...