The aromatic rings in guanine's structure make it a relatively stable molecule, but it can still undergo various chemical reactions, such as oxidation, reduction, and methylation. One of the most ...

Recent findings link DNA methylation entropy to chronological age, offering insights into epigenetic changes that could ...

Then, in 1983, Bert Vogelstein and Andrew Feinberg at Johns Hopkins University reported widespread loss of DNA methylation at cytosine-guanine (CpG) dinucleotides in tumor samples.1 This was the first ...

However, 5mC alone could not explain the second wave of extensive methylation, which targets short sequences of two nucleotides scattered all over coding genes, the so-called CG (cytosine-guanine) ...

The majority of DNA methylation occurs at CpG sites, which are cytosines that precede a guanine nucleotide. Traditionally, methylation is examined at a specific CpG site independently of any ...

The distinction between biological and chronological age is vital for risk assessment and interventions aimed at enhancing longevity and quality of life.