P. Comi, B. Giglioni, S. Ottolenghi, A. M. Gianni, E. Polli, P. Barba, A. Covelli, G. Migliaccio, M. Condorelli and C. Peschle PNAS is the world's most-cited ...

β-thalassemias are heterogeneous autosomal recessive hereditary anemias characterized by reduced or absent β-globin chain synthesis. Approximately 68,000 children are born with various thalassemia ...

Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a commercial-stage biopharmaceutical company focused on delivering innovative medicines for patients with rare diseases, today announced that the Committee ...

Mandy Boontanrart, PhD, a postdoc at ETH Zurich in Switzerland, has a particularly personal motivation for her research on a novel genetic therapy for sickle cell disease (SCD). She is a carrier of a ...

Whether you inherit alpha- or beta-thalassemia depends on which genes are affected. The number of affected genes can determine the subtype of alpha- or beta-thalassemia and the severity of your ...

Fetal hemoglobin (HbF) is the most dominant form of hemoglobin (Hb) in fetuses and persists until birth, at which time the production of adult Hb is upregulated. Both fetal and adult Hb contain alpha ...

Hemoglobin was obtained from the blood of lowland black and white cattle with HbA phenotype by the method of Drabkin. Water solutions of hemoglobin (Hb) or globin (Gl) in 20 mM KH 2 PO 4 were ...

Sickle cell disease is characterized by the painful recurrence of vaso-occlusive events. Gene therapy with the use of LentiGlobin for sickle cell disease (bb1111; lovotibeglogene autotemcel) consists ...

The blood protein hemoglobin and its relative, myoglobin, carry and store life-giving oxygen in many animals. Researchers long thought these complex proteins, with their unique fold, were the only two ...