05). Of those tested, 50 (17%) harbored a germline pathogenic or likely pathogenic variant. In the AMAZONA III trial, 1,476 (49%) of 2,974 patients with BC met the National Comprehensive Cancer ...

We found that maternal rRNAs are not only expressed during oogenesis but are continuously produced in the zebrafish germline. Proteomic analyses of maternal and somatic ribosomes unveiled differences ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

The scientific community also condemned his actions, and this self-regulation was crucial as it was a clear violation of guidelines that banned germline editing. But nonetheless “designer babies ...

This “innate memory” can be considered as germline-encoded because its effector tools (such as innate receptors) do not need somatic recombination for being active. Also, in several organisms the ...

The following section addresses the re-assessment of germline variants of uncertain significance using our approach, based on the clinical data, tumor type, personal and family history, and tumor ...

This paper challenges a fundamental view concerning why males of most animals have a higher germline mutation rate than females. Evidence is provided to show that it is not simply the fact that males ...