The HbF-to-HbA switch results in an imbalance of globin chains. Excess α-globin chains precipitate and damage red-cell precursors, which leads to ineffective erythropoiesis.

The amino acid glutamine plays an unexpected role in erythropoiesis, the differentiation of erythroid progenitor cells into mature red blood cells. Ordinarily, glutamine is broken down by stem ...

Zuccato, C., Cosenza, L.C., Zurlo, M., Lampronti, I., Borgatti, M., Scapoli, C., et al. (2021) Treatment of Erythroid Precursor Cells from -Thalassemia Patients with ...

Higher EPO and HIF lead to the secretion of ERFE from erythroid precursor cells, which attenuates the BMP6 signaling cascade via GDF15/TWSG1. In the absence of BMP6, TMPRSS6 binds to ALK2 ...

Knockdown of the CP β subunit increased erythroid maturation in murine ex vivo cultures and decreased colony forming potential of stress erythroid precursors. In a genetic complementation assay for ...

Erythroid precursor CFU‐Es comprised dense and pigmented colonies of very small cells overtly Benzidine + in high numbers (Appendix Fig S7D). All colony types were also obtained in the bulk assay ...

The primary components of the human erythroid are erythroid marrow and circulating red blood cells (RBCs). Erythrocin abnormalities that cause anemia fall into three categories: erythroid ...

During the process, multipotent hematopoietic stem cells differentiate into erythroid precursor cells, subsequently enucleated to form reticulocytes.

Panel (A) shows an erythroid precursor identified by a darker color in blue illumination due to the presence of Hb in the cell. The cell in panel (D) appears to be a marrow reticulocyte, based on its ...

Erythroid progenitors and multipotential progenitor numbers are comparable in all the bones except for reduced number in the parietal bone. In the femur, the epiphysis and metaphysis have ...

Erythropoietin (EPO), a 35-kDa glycoprotein, is the physiologically obligatory growth factor for erythroid development. Erythropoietin exerts its erythropoietic action by binding to the specific ...