Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing ...
Statement 1: DNA synthesis always proceeds in the 5' to 3' direction.
Protection of Genetic Material: The nuclear envelope shields the DNA from the mechanical and chemical stresses of the ...
DNA replication, a central event for cell proliferation, is the basis of biological inheritance. Complete and accurate DNA replication is integral to the maintenance of the genetic integrity of ...
Acquiring nucleotides is essential for all dividing cells, and failure to maintain sufficient levels and balance of nucleotides impairs DNA replication. Eukaryotic cells meet nucleotide demands ...
MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Sequences that form DNA secondary structures, ...
A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome
The eukaryotic replisome is assembled around the CMG (CDC45-MCM-GINS) replicative helicase, which encircles the leading-strand DNA template at replication forks. When CMG stalls during DNA replication ...
To initiate replication of double-stranded DNA genomes, the two interconnected strands must be separated to allow each strand to serve as a template for DNA synthesis. The initially unwound state is ...
The field of mitochondrial DNA (mtDNA) replication has been experiencing incredible progress in recent years, and yet little is certain about the mechanism(s) used by animal cells to replicate this ...
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