DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Characterizing gene promoters and promoter–terminator combinations is crucial for maximizing the benefits of bioengineering applications in plants. However, traditional methods of identifying ...

The tools needed to pinpoint the problematic variants have been lacking. To fill this gap, Farh and his team have developed a deep neural network—PromoterAI—that accurately identifies promoter ...

Researchers announce the release of an online tool that will help scientists find "gene promoters" -- regions along a DNA strand that tell a cell's transcription machinery where to start reading ...

Closely spaced, C-terminal ZnFs (ZnF456) recognize a specific DNA sequence, TGACCA, which is present in embryonic and fetal globin gene promoters but lacking in the adult β-globin promoter . 44 ...

Decoding plant gene expression: A deep dive into promoters and terminators for advanced bioengineering. In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Genetic elements like DNA promoters and terminators are crucial for creating this platform, since they control the expression of the “gene-of-interest.” While most promoter characterization ...

These new promoters work with AAV as well as other viral and non-viral gene-delivery systems. These new promoters will allow us to deliver larger genes or multiple small genes, and the genes can ...

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to a new gene therapy for Amyotrophic Lateral ...