A macrophage that has already fought off one infection does not return to a blank slate. It carries chemical scars, etched ...

Cancer drugs are designed to shut tumors down. But sometimes, in the very act of attacking a tumor, treatment can also help a small fraction of cancer cells become harder to kill. A new study from ...

New study uncovers triplex-mediated transcriptional activation driving tumor suppression in HCC Hepatocellular carcinoma (HCC ...

Charles W.M. Roberts, MD, PhD, executive vice president and Comprehensive Cancer Center director at St. Jude Children's ...

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create ...

Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways ...

As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA.

The retina is a highly specialized neural tissue characterized by extreme cellular differentiation, high metabolic demand, and lifelong exposure to environmental stressors. These features render ...

Epigenetic regulation of gene expression entails DNA methylation and histone modifications, which orchestrate chromatin structure and transcriptional activity. Aberrant regulation of these mechanisms ...

Prostate cancer is the most commonly diagnosed malignancy among men in Western countries and exhibits a remarkably heterogeneous clinical course, ranging from indolent tumors to rapidly progressive ...