Furthermore, we identified specific caRNA classes associated with individual transcription factors and histone modifications. Altogether, our findings reveal a RNase-inaccessible regulatory ...

What is striking, she adds, is that “there is relatively strong overlap with binding sites for BCL11A,” the transcription factor that Vertex successfully targets in its Casgevy cell therapy.

The primary regulator of pDC development is E2-2, controlled by a network of transcription factors, including BCL11A, ZEB2, and ID2. E2-2 also controls the expression of IRF8 via binding to the Irf8 + ...

Nuclear proteins, transcription factors (TFs), regulate many genes relevant to human diseases. Developing tools to study such TFs within intact cells is challenging. Miniature antibodies, nanobodies, ...

Researchers resolved human transcription factor (TF) regulation Date: February 9, 2022 Source: University of Helsinki Summary: A research team introduces a new large-scale study on human ...

The transcription factor BCL11A is known to be important for determining cell properties, for example in the cerebral cortex and also in the immune system. Prof.

Thus, it remains unknown if combinatorial gene regulation is primarily additive, multiplicative, or a wide distribution of everything in between (and beyond). Upstream of transcription, it is also ...

Prior molecular studies have identified master erythroid-lineage transcription factors (TFs)—Gata1, Tal1, and Klf1—and several adult-specific factors, namely Bcl11a, Sox6, and Myb (7 – 10).

Keywords: Bcl11a, Bcl11b, transcription factors, brain development, hippocampus, neocortex, neural circuitry, neurological disorders Citation: Simon R, Wiegreffe C and Britsch S (2020) Bcl11 ...

Initially, Biogen and Sangamo developed a strategy for beta-thalassemia that specifically knocked out the gene encoding the BCL11A transcription factor, a critical regulator of the switch from fetal ...

Arrows indicate transcription start sites. (b) ChIP analysis of KLF1 binding to the BCL11A promoter in human fetal liver cells and adult HEPs. The HBB promoter served as a positive control 26.