BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate ...

BCL11A: Evidence for neuroprotective effect Researchers at the University of Bonn investigate the role of the transcription factor for dopamine-producing neurons Peer-Reviewed Publication ...

Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis ...

A self-inactivating lentivirus vector with a short hairpin RNA designed to interfere with BCL11A expression was inserted into autologous hematopoietic stem cells of patients with sickle cell ...

BCL11A controlled hemoglobin, silenced fetal hemoglobin expression in adult erythroid cells You've successfully added to your alerts. You will receive an email when new content is published.

Williams believes the BCL11A-based approach to gene therapy for sickle cell disease will substantially increase the ratio of non-sickling versus sickling hemoglobin.

A gene has been identified that is especially active in aggressive subtypes of breast cancer. The research suggests that an overactive BCL11A gene drives triple-negative breast cancer development ...

A new study identifies a gene that is especially active in aggressive subtypes of breast cancer. The research suggests that an overactive BCL11A gene drives triple-negative breast cancer ...

Williams believes the BCL11A-based approach to gene therapy for sickle cell disease will substantially increase the ratio of non-sickling versus sickling hemoglobin.

Researchers say knocking out BCL11A switches cellular production of haemoglobin from mutated adult form to normal fetal form.

Stuart Orkin of Harvard Medical School in Boston, and colleagues, knocked out the BCL11A gene from mice belonging to a strain that normally develops a sickle cell-like condition.

BCL11A: Evidence for neuroprotective effect Date: September 14, 2021 Source: University of Bonn Summary: The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A ...