Selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs) are types of antiestrogen therapy for breast cancer. These medicines block estrogen, the ...

Additionally, antiestrogen treatments for ER- and PR-positive breast cancer can cause the resistance mutation ESR1, explained Guinigundo. In these situations, estrogen blockers become less effective ...

The estrogen receptor-positive (ER+) subtype accounts for 70% of all mammary carcinoma (MC) cases. ER+ MC patients display a prolonged clinical dormancy state, with a 70% recurrence 5-20 years after ...

The complexity of the underlying genotypes of acquired antiestrogen resistance include multiple genetic mechanisms and epigenetic changes, reviewed herein, indicating that the breast cancer cells have ...

Collectively, our data have demonstrated the function of MYSM1 on maintenance of ERα stability and modulation of ERα action to confer antiestrogen insensitivity in ERα-positive breast cancer, ...

Immune cells infiltration and activation are higher in breast cancers resistant to antiestrogen therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; ...

A pilot study investigated the effects of a nurse-led education intervention for patients receiving antiestrogen therapy for high risk of breast cancer or to prevent disease recurrence.

Your Good Health: Antiestrogen drugs rarely used to treat erectile dysfunction Dear Dr. Roach: I have a bad case of erectile dysfunction. I am 80 years old and otherwise in good health.

Endocrine Therapy and Mechanism of Action Endocrine therapy is the most efficacious drug for the treatment of ER-positive breast cancer patients (37). Based on their chemical structure, endocrine ...

We can offer antiestrogen therapy in the adjuvant setting, and we have data for supporting antiestrogen therapy with anti–HER2-based therapies in the metastatic setting for these patients. Ruta Rao, ...

Clomid is a non-steroidal antiestrogen, generated to treat female infertility. Clomid fragments increase an energy level in its active, and increases an inhalation level in a low level of chronic sex ...