Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has described proteolysis targeting chimeric (PROTAC) compounds comprising a protein cereblon (CRBN) ligase binding moiety covalently linked to an ...

Davis R Ingram; Lloye M Dillon; Dina Chelouche Lev; Alexander Lazar; Elizabeth G Demicco; Burton L Eisenberg; Todd W Miller ...

His contributions to medicinal chemistry and bioorganic chemistry are many, particularly in the study of estrogen and androgen receptors, serine proteases and radiopharmaceuticals (see the related ...

This indicates that GLP-1 receptor agonists lead to greater reduction in overall body fat than that in muscle mass, resulting in an overall body fat percentage decrease of around 4.5%.

Nuclear receptors regulate transcription in response to ligand signals and enable the pharmacological control of gene expression. However, many nuclear receptors are still poorly explored and are not ...

Homologous recombination deficiency signature (HRDsig+) and the genomic landscape of clinically advanced prostate carcinoma (CAPC). This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary ...

Sweet taste receptors in the heart: A new pathway for cardiac regulation New research shows that the heart can sense sweeteners and can increase the force of heart muscle contraction in response ...

Additionally, their research may explain why high consumption of artificially sweetened beverages is linked to arrhythmogenesis, or an irregular heartbeat. Not only are these sweet taste receptors ...

Dihydrotestosterone (DHT) is an androgen that promotes the growth of facial hair ... Testosterone and DHT both bind to the same receptors. However, DHT does so more efficiently. Most DHT and ...

In patients with castration-resistant prostate cancer (CRPC), clinical resistances such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) limit the effectiveness of ...