Chinese scientists have developed a novel AI-guided protein engineering strategy that enables faster, cost-effective, and ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called ...

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of ...

Professor Sir Shankar Balasubramanian, from Cambridge, has won the Royal Society of Chemistry’s Khorana Prize in recognition ...

Conclusion: This study demonstrates the effectiveness of adenine base editing to treat MSMDS and restore aortic smooth muscle function. By correcting the ACTA2 R179H mutation, the pathogenic ...

It is based on YolTech's proprietary adenine base editor, YolBE—specifically hpABE5—which comprises nCas and a novel deaminase evolved from Hafnia paralvei.

In a global first, scientists have used advanced base editing to repair a deadly gene mutation in a newborn, marking a major leap forward in the treatment of rare inherited metabolic diseases.

Conclusions: This study demonstrates the effectiveness of adenine base editing to treat MSMDS and restore aortic smooth muscle function. By correcting the ACTA2 R179H mutation, the pathogenic ...

To develop a patient-specific, bespoke gene editor, we screened various adenine base editors (ABEs) with guide RNAs (gRNAs) tiling the site of the Q335X variant in the lentivirus-transduced HuH-7 ...

For example, enzymes like methyltransferases can attach methyl groups to certain parts of DNA, typically on cytosine or adenine bases. Such chemical modifications can change how genes are expressed.