In a new proteomics extravaganza, scientists have unearthed groups of proteins that appear to be at the heart of Alzheimer’s disease pathogenesis. As described in Cell on September 25, scientists led ...

Doctor of Philosophy (PhD) University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology Graduate Certificate in Public Health Preparedness and ...

Synonyms: High-copy SOD1-G93A, B6SJL.SOD1-G93A, Tg(hSOD1-G93A)1GUR mice, Gurney mice ...

Whether by way of a soccer ball or another player’s head, sustaining too many whacks to the noggin leaves a visible mark on the brain. This was the common conclusion of two very different studies that ...

Cellular aging is a central feature of neurodegenerative diseases, and microglia, the brain’s resident immune cells, are especially susceptible. Alas, whether this reflects intrinsic wear and tear or ...

In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...

Scientists have uncovered a potential new mechanism whereby α-synuclein pathology spreads. Like black holes, large densities of α-synuclein pull in surrounding matter. Among the victims trapped in ...

Could a single nucleotide switch safeguard decades of brain health before Alzheimer’s sets in? Researchers know that this is what the rare apolipoprotein E3 Christchurch variant does, but how it pulls ...

With several antibodies to mop up amyloid plaques coming into routine use, the big challenge for scientists has become to find ways to temper tau pathology. Two different studies report some news on ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

The digital microscopy platform for neurodegenerative diseases is being developed by Jochen Herms and Sigrun Roeber at the Center for Neuropathology and Prion Research of Ludwig Maximilian University, ...