Ms. Charleson played Dr. Monica Quartermaine, a cardiologist and family matriarch, on the daytime series for 46 years.

Leslie Charleson, best known for her long-time role on General Hospital, has died. She was 79. The actress's death was announced via a post on the official General Hospital Instagram, which featured a smiling picture of Charleson accompanied by words from executive producer Frank Valenti.

Soap opera veteran Leslie Charleson, who played Monica Quartermaine on "General Hospital," has died at the age of 79.