Nolan Bianchi, John Niyo, Richard Silva and Bob Wojnowski of The Detroit News offer predictions for Monday's Lions-49ers game ...

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San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

Detroit Lions defensive coordinator Aaron Glenn called San Francisco 49ers TE George Kittle 'the best tight end in the game.' ...

The Detroit Lions and San Francisco 49ers will square off in a rematch of last year's NFC Championship game on Monday Night ...

This isn't the same 49ers team the Lions lined up against 11 months ago, but Detroit is still treating it like a marquee game ...

The Lions held a 17-point lead in the NFC championship game over the San Francisco 49ers before getting outscored 27-7 in the ...

Coach Dan Campbell stood at the podium after Detroit blew a 17-point lead to San Francisco in last season's NFC title game ...

The 49ers are eliminated from the playoffs. But don't tell Kittle or Samuel that, with both studs having two of their best ...

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Monday Night Football game between Detroit Lions ...

Richard Silva of The Detroit News breaks down the Lions' Week 17 game against the San Francisco 49ers.