Hosted on MSN29d
Bacterial small RNA promotes gut colonization by regulating sialic acid metabolism, research reveals
Moreover, functional studies revealed that ManS isoforms with a single seed region directly regulate Neu5Ac/ManNAc metabolism by repressing the GlcNAc phosphotransferase system permease NagE.
Frontiers22d
An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant Escherichia coli
Their molecular functions were primarily related to carbohydrate transmembrane transporter activity (52 proteins), protein-phosphocysteine-sugar phosphotransferase activity (18 proteins), carbohydrate ...
eLife6d
Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions
Polyphosphate (polyP) exists in all life forms; however, its biological functions in metazoans are understudied. Here, we explored Drosophila as the first genetic model to explore polyP biology in ...
Frontiers28d
Clinical evidence of immunogenicity of CAR-T cell therapies and its implication in the clinical development of CAR-T drug products
Chimeric antigen receptor-engineered T cell therapies (CAR-T) are becoming powerful immunotherapeutic tools for treating malignancies, especially hematological malignancies. Like other biological ...
eLife23d
Aeromonas hydrophila CobQ is a new type of NAD
In this valuable study, the authors studied a novel Zn2+- and NAD+-independent KDAC protein, AhCobQ, in Aeromonas hydrophila, which lacks homology with eukaryotic counterparts, thus underscoring its ...
C&EN21d
Toward Antibody Production in Genome-Minimized Bacillus subtilis Strains
University Medical Center Groningen, Department of Medical Microbiology, University of Groningen, Hanzeplein 1, P.O. Box 30001, 9700RB Groningen, The Netherlands ...
C&EN21d
Transition State Analysis of SAMHD1 from Primary
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States ...