Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets ...

Steroid Hormone Receptors So far, the specific role of the estrogen receptors and progesterone receptors in renin expression has not been addressed directly. Renin levels fluctuate with the menstrual ...

The issue is, unlike nuclear hormone receptors such as ERRs, PGC1α cannot bind to genes directly, so it relies on partner proteins to get the job done.

A new Salk Institute study suggests that estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue.

Nuclear receptors regulate transcription in response to ligand signals and enable the pharmacological control of gene expression. However, many nuclear receptors are still poorly explored and are not ...

These nuclear receptors can be activated by a range of ligands – such as vitamins, hormones and fatty acids – which trigger the receptor to upregulate the transcription of certain genes (Nagy and ...

Our goal is to investigate the mechanisms that nuclear hormone receptors drive tumor progression, drug resistance and/or metastasis and to identify new drug targets for potential treatment. We ...

Nuclear hormone receptors are also found in most animals, including humans, suggesting that similar metabolite detection systems might exist in other organisms.

Nuclear hormone receptors (NHRs) are ligand-activated transcription factors that can recognize a variety of small molecules, including lipids, hormones, vitamins, and metabolites of amino acids.

This shape-shifting ability helps explain some long-standing observations about androgen hormones, including the fact that they play many roles in development and adulthood. The androgen receptor is ...

We further show that nuclear hormone receptor nhr-67 is a negative regulator and homeodomain-interacting protein kinase hpk-1 is a positive regulator of the NHR-49 pathway. Together, our experiments ...