This enzyme's selectivity for RNA, its high methylation activity ... an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency, Nucleic Acids Research (2024).

The authors designed elegant experiments to confirm the METTL3 works through genomic DNA, adding the methylation into DNA (6mA) but not the RNA (m6A), in this base damage repair context. The authors ...

The subsequent symptom of advanced DCM is heart failure. The present study focused on the role and mechanism of RNA methylation modifications (m6A, m5C, and m1A) in DCM, aiming to uncover shared ...

RUNX3 is identified as a critical transcription factor influencing lung development and inflammation, while changes in DNA methylation and histone dynamics in cord blood are linked to immune ...

Proteins that bind m6A in RNA, often referred to as “readers,” have various ... The increased presence of 6mA during DNA damage could result from methylation at a prexexisting unmodified A base ...

Equally compelling are the roles of snoRNAs and snRNAs, which modulate ribosomal function, RNA methylation, and mRNA splicing. Dysregulation of these molecules correlates with adverse ...

The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic synthesis of lipoprotein(a), are unknown. We randomly assigned participants in a 1:2:2:2:2 ...

This pathway, or others like it, could explain why some inheritable traits between generations can’t be explained exclusively via DNA and RNA. "There are a lot of traits and disorders that we ...

“When I did the review I met with RNA officials and it was glaringly obvious it needed a facelift. “It just wasn’t going to work (as the main stadium) within the budget framework and ...