The switch from HbF (α2γ2) to HbA (α2β2) is critical in the pathophysiological processes underlying the major hemoglobin disorders, which are caused by mutations of the β-globin gene .

The first healthy volunteer has been dosed in a Phase 1 study of Cellarity's novel globin-switching therapy CLY-124 for ...

New research by HHMI scientists shows it's possible to reactivate production of fetal hemoglobin production in adult mice and effectively reverse sickle cell disease. The new studies show that ...

Hemoglobin abnormalities, including those resulting from globin-gene mutations, cause a variety of clinical symptoms, including cyanosis. 1 Hemoglobin is a tetramer of two α-like and two β-like ...

Huang P, Peslak SA, Shehu V, et al. let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood. 2024;143(19):1980-91. PubMed PMID: 38364109. Do BT, Hsu PP, Vermeulen SY ...

Japan: Researchers have found in a new study that Roxadustat therapy in non-dialyzed chronic kidney disease (CKD) patients may lead to hemoglobin (Hb) overshoot, particularly when switching ...

In another approach, CRISPR-Cas9 is used to switch on a gene that encodes a different kind of hemoglobin called fetal hemoglobin. This hemoglobin normally only works during fetal development .