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Heme is the iron-containing prosthetic group of heme proteins, with varied functions ranging from gas carriers (i.e., hemoglobin) to metabolic enzymes (i.e., cytochromes, indoleamine dioxygenases).

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States Collaborative Mass Spectrometry Innovation Center, University of ...

Recent evidence regarding the crosstalk between erythropoiesis and iron metabolism sheds light on the regulation ... iron complexed within the porphyrin ring of heme, and iron within iron-sulfur ...

Mechanisms have been controversial but recent evidence suggests that caveolar transcytosis across endothelial cells is the dominant pathway. Receptors involved are LDLR (LDL receptor), SR-B1 ...

showing that porphyrin catabolism was regioselective at the α-position. Finally, through the analysis of a control inactive analogues, we showed that close structural analogues of heme are required to ...

Iron accumulation also affects the phosphorylation status of tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis, interfering with the dopamine signaling pathway. On the other hand, ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. 2Cancer Institute, Suzhou Medical College, Soochow University, Suzhou, China. 7Suzhou Biomedical ...

School of Biosciences, Faculty of Health and Medical Sciences. Professor Margaret Rayman has a doctorate in Inorganic Biochemistry from Somerville College, Oxford, and has held post-doctoral ...