Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis ...

It is essentially an alternative catabolic pathway that is activated and supplied by elevated intracellular glucose levels. [31, 37] The first redox reaction of the polyol pathway couples the ...

The identities of the degradation products following catabolism were confirmed by MALDI-MS and LC−MS, showing that porphyrin catabolism was regioselective at the α-position. Finally, through the ...

Simultaneously, attributed to the released functional ions, the prepared composite scaffolds significantly enhanced the synthetic metabolism in chondrocytes and inhibited the expression of ...

In flavocytochrome P450 BM3, there is a conserved phenylalanine residue at position 393 (Phe393), close to Cys400, the thiolate ligand to the heme. Substitution of Phe393 by Ala, His, Tyr, and Trp has ...