Learn what distinguishes alpha- from beta-thalassemia and how they differ in their symptoms and outlook. ... you inherit a total of four α globin genes and two β globin genes from your parents.

Alpha thalassemia results from defective alpha globin genes, while beta thalassemia involves mutations in beta globin genes. "Beta thalassemia major, also known as Cooley’s anemia, is often more ...

Most healthy hemoglobin includes two proteins: alpha-globin and two beta-globin. ... If a child inherits problems with one of two beta-globin genes, they’ll have the beta-thalassemia trait.

These genes control your body's production of the two proteins that make up hemoglobin, called alpha globin and beta globin. Six genes, three from each parent, are responsible for these two proteins.

Alpha-globin and beta-globin protein chains make up hemoglobin. Changes in the alpha- or beta-globin genes that provide instructions for these proteins can lead to thalassemia.

Four genes are responsible for making alpha globin. The more genes a person is missing, the more severe their alpha thalassemia will be. People missing one gene will be carriers.

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

Mutations in the beta-globin gene cause sickle cell disease and beta-thalassemia. But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of ...

In HbA2, which makes up less than three percent of the total Hb protein, the alpha chains pair with a pair of delta globin chains. The delta globin gene sits upstream of the closely related beta ...

The presence of a gene for beta thalassemia in the father was suggested by the disparity of the diseases in the mother and her children, and was confirmed by the determination of a mean beta-alpha ...

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.