Since protein transduction domain (PTD) technology has emerged as a promising therapeutic approach, we produced a human recombinant β-globin chain in fusion with the TAT peptide and successfully ...

World Thalassemia Day was observed on 8 May. India records between 10,000 and 15,000 new cases of Thalassemia Major every year, with national carrier rates estimated at 3 to 4 per cent, and as ...

Berlin, 16 December – The transition to electric vehicles (EVs) is driving a surge in demand for batteries and the materials required to produce them. A new study from the International Council on ...

Sickle cell disease causes red blood cells to become rigid and sickle-shaped, resulting in frequent pain and anemia, while thalassemia causes abnormal hemoglobin due to deficient globin chains. 1 ...

Alpha thalassemia is inherited anemia where the body cannot produce a normal amount of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen throughout your body. Hemoglobin A ...

Alpha-globin and beta-globin protein chains make up hemoglobin. Changes in the alpha- or beta-globin genes that provide instructions for these proteins can lead to thalassemia.

Over 95% of typical adult hemoglobin is made up of two alpha (α) and two beta (β) globin protein chains. Each α and β chain can bind an oxygen molecule from your lungs and deliver it to ...

Symptoms are severe. Sickle beta+-thalassemia: One beta-globin gene makes sickle hemoglobin, and the other makes a reduced amount of healthy hemoglobin. Symptoms are often milder.

The delta globin gene sits upstream of the closely related beta globin gene in a gene cluster on chromosome 11. Attention turns to the delta globin gene on chromosome 11 as a potential key to ...

Website: https://www.ebi.ac.uk/complexportal/home Publication: https://academic.oup.com/nar/article/50/D1/D578/6414048 Description: The Complex Portal is a manually ...