The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related ... of patients with ALS who do not manifest ...

Spinal bulbar muscular atrophy (SBMA) causes a loss of motor neurons in the spinal cord and brainstem. It mainly affects facial and swallowing muscles and the muscles in the arms and legs.

Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of ...

Pamela Shaw is an academic neurologist and a world-leading researcher in motor neuron disease (MND). She has held extensive leadership roles at local/national ...

Frontotemporal dementia also called FTD, is a rarer type of dementia caused by a build up of proteins, tau, FUS and TDP-43, in the frontal and temporal lobes of the brain. Dementia is caused by ...

Directly inherited dementia is rare, but in around three in every 10 people with FTD a strong family history of the condition is known. In these cases the cause is likely to be genetic. This is known ...

We have noted that a subgroup of patients with classic ALS present with progressive wasting and weakness of the arms, with little or no functional impairment of the bulbar muscles ...