Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...

The aim is to work out how these components fit into signal transduction pathways ... apoptosis, necroptosis and pyroptosis. Keywords: hematopoietic stem cell, skeletal stem cell, melanoma, metastasis ...

Apoptosis, the dominant form of programmed cell death, refers to the shedding of the leaves from trees in Greek. The distinct morphological changes of cells undergoing apoptosis are sequentially ...

School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China ...

We conduct clinical and preclinical research to expand knowledge, improve survival and reduce suffering in eye cancer and diseases of the eyelids and lacrimal system. A variety of different tumors can ...

There are two major mechanisms for apoptosis: intrinsic apoptosis and extrinsic apoptosis. In both extrinsic and intrinsic apoptosis, the first caspases activated by either APAF-1 or DISC are called ...

In summary, this work reveals the role of CB in inducing DNA damage and cell apoptosis involved in the activation of the ATM/CHK2/p53 signaling pathway, and indicates ... that the research was ...

Hematopoietic stem cell (HSC) aging, which is accompanied by loss of self-renewal capacity, myeloid-biased differentiation and increased risks of hematopoietic malignancies, is an important focus in ...

However, it remains unclear if viral infection has any impact on the N-end rule pathway. Here, using a picorna-like virus as a model, we found that viral infection promoted the accumulation of caspase ...

These differences in rate of apoptosis negatively correlate with region-dependent levels of activity. Disrupting this activity either pharmacologically or by electrical stimulation alters the spatial ...