Glial cells support neurological structures, function, cognition, behaviours, physical skills, and motor coordination.

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Interferon regulatory factor 5 (IRF5) is a transcription factor activated downstream of Toll-like receptors (TLRs) 7, 8 and 9, and is predominantly expressed in dendritic cells, B cells, monocytes and ...

About Dubodencel Dubodencel, also known as DOC1021, is a first-in-class, double-loaded autologous dendritic cell therapy that uniquely combines tumor lysate and amplified tumor-derived mRNA. The ...

Vaccine may improve breast cancer treatment outcomes Dendritic cell vaccine shows potential to enhance chemotherapy effectiveness in HER2-postitive, ER-negative subtype Date: March 18, 2025 Source ...

Dendritic cells are principal antigen-presenting cells and initiators of the immune response in allergic asthma. Their phenotype, guided by multiple factors may dictate the immune reaction to an ...

CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.

Autoimmune pancreatitis (AIP) is a clinical condition characterized by inflammation of the pancreas, caused by the body's hypersensitivity to its own proteins. AIP is typically accompanied by other ...

By Pooja Toshniwal Paharia New research reveals how common dietary proteins like bovine serum albumin (BSA) or ovalbumin (OVA ...

Immunotherapies have shown limited responses in patients with advanced pancreatic cancer. Recently, we reported that dendritic cell (DC)–based immunotherapy induced T-cell responses against pancreatic ...

Dendritic cells (DCs) regulate the immune response associated with T lymphocytes, but their role in stroke remains unclear. In this study, we investigated the causal relationship between DCs and ...

Plasmacytoid dendritic cells (pDCs) are the major producers of type I interferons (IFNs), which are essential to mount antiviral and antitumoral immune responses. To avoid exaggerated levels of type I ...