Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

The tools needed to pinpoint the problematic variants have been lacking. To fill this gap, Farh and his team have developed a deep neural network—PromoterAI—that accurately identifies promoter ...

Closely spaced, C-terminal ZnFs (ZnF456) recognize a specific DNA sequence, TGACCA, which is present in embryonic and fetal globin gene promoters but lacking in the adult β-globin promoter . 44 ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Our cells' identity is shaped by DNA tags called methylation. New tech, scDEEP-mC, maps these tags in single cells with ...

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to a new gene therapy for Amyotrophic Lateral ...

A team at the Peter Mac is planning for first-in-human trials in five years, hoping this new therapy will eschew the ...

Cite this: Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research - Medscape - Dec 01, 2006. Abstract and Introduction Insulin Gene Expression ...