While novel coronavirus is undergoing many mutations, one particular mutation called D614G, according to a study, has become the dominant variant in the global COVID-19 pandemic.

More information: Chenxu Guo et al, The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation, Science Advances (2022).

Credit: Bing Chen, PhD, Boston Children's Hospital, CTV News Why Does the D614G Mutation Make the Delta Variant More Infectious? There is a reason for this, and it's fascinating, But let's leave that ...

This work is published in Science, in the paper, “ Structural impact on SARS-CoV-2 spike protein by D614G substitution. ” In the original coronavirus, the spike proteins would bind to the ACE2 ...

SARS-CoV-2 spike D614G change enhances replication and transmission. Nature, 2021; DOI: 10.1038/s41586-021-03361-1 ...

The D614G variant carries a mutation in the spike protein that makes it easier for the virus to dock onto human cells. The researchers at IVI and in David E. Wentworth's laboratory at the Centers ...

The D614G mutation in the SARS-CoV-2 spike protein--commonly referred to as the "G variant"--likely emerged in early 2020 and is now is the most prevalent and dominant form of the SARS-CoV-2 virus ...

In a recent study, Plante et al. used reverse genetics to recover isogenic recombinant SARS-CoV viruses encoding the D614G mutation. 5 The G614 variant replicated more efficiently than did the ...

Figure 6. D614G mutation increased the amount of RBD 2 open and 3 open. Image Credit: ACROBiosystems As it stands, around 200 COVID-19 vaccine development studies are ongoing.

The D614G mutation causes a flap on the tip of one spike to pop open, allowing the virus to infect cells more efficiently but also creating a pathway to the virus’ vulnerable core.