Here, we produce a DNA nanostructure decorated with controlled numbers of engineered single-chain TNF-related apoptosis-inducing ligand ... could be caused by the saturation of the intrinsic signaling ...

The current investigation exhibited the anticancer effect of nimbolide against N-methyl-N-nitrosourea (MNU) induced gastric cancer (GC) rats via apoptosis and NF-κB signaling pathway. Male Swiss ...

In this paper, we investigate the problem of extrinsic and intrinsic calibration of perception systems. Traditionally, targets in the form of checkerboards or uniquely identifiable tags are used to ...

There are two major mechanisms for apoptosis: intrinsic apoptosis and extrinsic apoptosis. In both extrinsic and intrinsic apoptosis, the first caspases activated by either APAF-1 or DISC are called ...

TNF-α and IL-1β promoted myeloid-biased differentiation and inflammatory pathway blockade may rejuvenate aged HSC functions and increase B cell output (Figure 6B). HSC aging is a comprehensive result ...

Figure 4. Apoptosis pathway. Two apoptosis activation mechanisms are the extrinsic and intrinsic pathways. The extrinsic pathway, including Fas path and TNF path, is activated by ...

What determines how we move in the world? Motor neuroscience often focusses either on intrinsic rhythmical properties of motor circuits or extrinsic sensorimotor feedback loops. Here we show that the ...

However, it remains unclear if viral infection has any impact on the N-end rule pathway. Here, using a picorna-like virus as a model, we found that viral infection promoted the accumulation of caspase ...