The first-of-its-kind Edwards Lifesciences Sapien M3 TMVR system uses a nitinol dock to anchor the replacement valve in the ...

In patients greater than age 65, more than 90% of aortic stenosis involves trileaflet valves which have developed heavy calcification ... alter the structure and motion of the valve leaflets ...

The most common cause of aortic stenosis in a person over age 70 years is calcification of a normal ... In this setting, rheumatic mitral valve disease is almost always present.