CRISPR libraries enable scientists to systematically investigate gene functions, identify novel drug targets, and develop personalized therapies.

A high throughput screen of >30,000 diverse repressor domains ... X-Repressors (ELXRs), making them more potent than current Cas9-based repressors. ELXR offers a promising epigenetic editing ...

Novel therapeutic targets for colon cancer were identified by Genome-wide CRISPR-Cas9 dropout screen of patient-derive colon cancer organoids. In a model of pancreatic ductal adenocarcinoma ...

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR ...

Researchers from Tel Aviv University utilized CRISPR to cut a single gene from cancer cells of head and neck tumors—and ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

At the heart of this technology is the Cas9 protein, often likened to molecular ... where analytical chemistry and life science collide, CRISPR’s growing influence is unmistakable, taking ...

Building a gene editor took months. With CRISPR even high-schoolers can get hold of editing systems in the time it takes to ...

As reported on Tuesday in PNAS Nexus, opens new tab, Japanese researchers used the CRISPR-Cas9 gene editing system to eliminate the third chromosome in trisomy 21 cells grown in test tubes.

In a study published in Nature Communications, researchers at the Beijing Institute of Stem Cells and Regeneration (BISCRM) and the Institute of Zoology (IOZ) have cracked the code of the notorious ...