The association of BCL11A with the HbF level was unanticipated, but BCL11A was previously identified as an essential transcription factor for B-lymphocyte development in knockout mice. 31 BCL11A ...

Genetic and functional studies have identified BCL11A as a critical mediator of the fetal-to-adult hemoglobin switch in humans and as a silencing factor for the γ-globin genes in adults. 1,25,26 ...

The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell Reports , 2021; 36 (11): 109697 DOI: 10.1016/j.celrep.2021.109697 Cite This Page : ...

Researchers resolved human transcription factor (TF) regulation. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2022 / 02 / 220209112141.htm. University of Helsinki.

The BCL11A transcription factor is the protein responsible for shutting off the gene for HbF shortly after birth as the body transitions to the adult version. With the CRISPR/Cas9 snip, BCL11A is ...

There are many different kinds of transcription factors, with each acting upon defined sets of genes, sometimes with multiple transcription factors working together to regulate gene expression.The ...

The transcription factor BCL11A is known to be important for determining cell properties, for example in the cerebral cortex and also in the immune system. Prof.

Nuclear factors are known to control a plethora of genes and organogenesis during development and their aberrant activity is linked to several human cancer types. Our data suggest that transcription ...