SEs are large and multi-kilobase regions of the genome that cover multiple enhancers. SEs are commonly located in the SE domains, specifically within the topologically associating domain (TAD), an ...

EPB41L4A-AS1 is a complex lncRNA gene. The EPB41L4A-AS1 locus is ∼2 kb (kilobases) long, and the main transcribed isoform terminates ∼300 nt from the 3’ end of the main isoform of the convergently ...

The use of chemical permeation enhancers (PEs) to improve the permeation of peptides across gastric and intestinal epithelia has proven an effective strategy in the development of oral dosage forms of ...

In this manuscript, Wolfson and co-authors demonstrate a combination of an injury-specific enhancer and engineered AAV that enhances transgene expression in injured myocardium. The authors ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...