Chinese scientists have developed a novel AI-guided protein engineering strategy that enables faster, cost-effective, and ...

A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called ...

The scientists noted that adenine base editors may overcome many of the challenges associated with other gene therapy approaches because the treatment is better tolerated by cells compared to Cas9 ...

Metagenomi Adenine Base Editors (ABEs) demonstrated over 95% genome targetability Simultaneous ABE triplex editing resulted in over 95% protein knockdown in primary T-cells ABE demonstrated highly ...

New research demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic ...

Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed. The ...

Komor developed two tools, an adenine base editor (ABE), which converts an A base to G base, and a cytosine base editor (CBE), which converts a C base to a T base.

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants Beijing Zhongke Journal Publising Co. Ltd. Journal ...

Preclinical evaluation of this novel base-editing strategy involved both in vitro and in vivo studies, which led to the identification of a single combination of both the adenine base editor (ABE ...

To develop a patient-specific, bespoke gene editor, we screened various adenine base editors (ABEs) with guide RNAs (gRNAs) tiling the site of the Q335X variant in the lentivirus-transduced HuH-7 ...