A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called ...

Chinese scientists have developed a novel AI-guided protein engineering strategy that enables faster, cost-effective, and ...

The scientists noted that adenine base editors may overcome many of the challenges associated with other gene therapy approaches because the treatment is better tolerated by cells compared to Cas9 ...

Metagenomi Adenine Base Editors (ABEs) demonstrated over 95% genome targetability Simultaneous ABE triplex editing resulted in over 95% protein knockdown in primary T-cells ABE demonstrated highly ...

New research demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic ...

Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed. The ...

In vivo base editing enables precise, single-nucleotide changes to DNA without double-strand breaks. A recent application in ...

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants Peer-Reviewed Publication Beijing Zhongke ...

Portfolios have building blocks that determine whether family capital survives market shocks, tax‑code changes and ...

Komor developed two tools, an adenine base editor (ABE), which converts an A base to G base, and a cytosine base editor (CBE), which converts a C base to a T base.

To develop a patient-specific, bespoke gene editor, we screened various adenine base editors (ABEs) with guide RNAs (gRNAs) tiling the site of the Q335X variant in the lentivirus-transduced HuH-7 ...