Some dermatologists may prescribe topical spironolactone for acne as a custom formulation that a compounding pharmacy can make. The closest alternative to compounded topical spironolactone is ...

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...