GEN

HIV’s Capsid Transports the Viral Genome into the Cell’s Nucleus

In order for HIV to replicate, the viral genome must enter into the cell nucleus and integrate into the host cell chromosome. Previous work suggests that the entry proceeds through nuclear pore ...
Science Daily

First atom-level structure of packaged viral genome reveals new properties, dynamics

A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and ...
The Scientist

Gilead’s Capsid Revolution Meets Our Capsid Solutions: Sino Biological – Engineering the Tools to Outsmart HIV

The FDA granted priority review, with a decision expected by June 19, 2025. LEN represents a novel class of HIV therapies by targeting the viral capsid, a multifunctional protein essential for HIV ...
The University of Chicago Chronicle

Simulations show how HIV sneaks into the nucleus of the cell

Because viruses have to hijack someone else’s cell to replicate, they’ve gotten very good at it—inventing all sorts of tricks. A new study from two University of Chicago scientists has revealed how ...
The University of Chicago Chronicle

Tiny ion is crucial for HIV replication, say UChicago chemists

A study by chemists at the University of Chicago has uncovered a new key step in the process that HIV uses to replicate itself. The study, published Jan. 6 in Science Advances, used computer modeling ...
News Medical

Gilead’s capsid revolution meets our capsid solutions: Sino Biological – Engineering the tools to outsmart HIV

Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir (LEN), a groundbreaking twice-yearly injectable HIV-1 capsid inhibitor for ...