The EMBO Journal11d
Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
A NOTCH1-SOX2 negative feedback mechanism was linked with resistance to GSI. SOX2-induced inhibition of Notch signaling in ...
The EMBO Journal5d
Rett syndrome: interferon-γ to the rescue?
In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...
The EMBO Journal8d
TRPC5: a new entry to the chromaffin cell’s palette of ion channels that control adrenal response to hypoglycemia
Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...
The EMBO Journal11d
Brain mitophagy in space and time
A new resource by Rappe et al (2024) now provides a spatiotemporal landscape of mitophagy changes during mouse brain aging at ...
The EMBO Journal4d
Making contact away from home: a bacterial secreted effector mediates inter-organelle communication
Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...
The EMBO Journal9d
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy
Eicosapentaenoic acid (EPA) prevents diabetic cardiomyopathy (DC) by promoting the transition of macrophages from M1 to Mox ...
The EMBO Journal11d
Liver DE(HP)toxification: luteolin as “phthalates-cleaner” to protect from environmental pollution
Environmental pollution is a major health problem that affects the health of individuals worldwide and is cumulative with ...
The EMBO Journal13d
Deep quantification of substrate turnover defines protease subsite cooperativity
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Substrate specificity determines protease ...
The EMBO Journal1d
Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity
The hair follicle is thought to be a site of ‘immune privilege,’ or relative protection from autoimmune and inflammatory responses. In particular, the long-lived, quiescent hair follicle stem cells ...
The EMBO Journal1d
Glutamine sensing licenses cholesterol synthesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...
The EMBO Journal6d
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid droplets (LDs) serve as crucial hubs for ...
The EMBO Journal6d
Identifying T-cell clubs by embracing the local harmony between TCR and gene expressions
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. T cell receptors (TCR) and gene expression ...